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Decreased glomerular filtration as the primary factor of elevated circulating suPAR levels in focal segmental glomerulosclerosis

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Abstract

Background

Circulating factor(s) has been thought to be the underlying cause of focal segmental glomerulosclerosis (FSGS), and recent studies foster this idea by demonstrating increased soluble urokinase receptor (suPAR) levels in the serum of FSGS patients.

Methods

To explore the possible contribution of suPAR in FSGS pathogenesis, we analyzed serum suPAR levels in 17 patients with FSGS and compared them with those in patients with steroid-sensitive nephrotic syndrome, chronic glomerulonephritis, or non-glomerular kidney diseases.

Results

Serum suPAR levels in patients with FSGS were higher than those in patients with steroid-sensitive nephrotic syndrome or chronic glomerulonephritis, but not higher than those in patients with non-glomerular kidney diseases. suPAR levels negatively correlate with estimated glomerular filtration rate and were decreased after renal transplantation in patients with FSGS as well as in those with non-glomerular kidney diseases. Furthermore, 6 FSGS patients with post-transplant recurrence demonstrated that suPAR levels were not high during the recurrence.

Conclusions

Based on our results, elevated suPAR levels in FSGS patients were attributed mainly to decreased glomerular filtration. These data warrant further analysis for involvement of possible circulating factor(s) in FSGS pathogenesis.

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Acknowledgements

This work was supported, in part, by a Grant-in-Aid for Scientific Research (B) (22390204 to YH, SH and TI) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

Disclosure

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Yutaka Harita, Haruko Tsurumi, Kenichiro Miura, Akira Oka & Takashi Igarashi

  2. Department of Pediatric Nephrology, Tokyo Women’s Medical University, Tokyo, Japan

    Kiyonobu Ishizuka, Noriko Sugawara, Hiroko Chikamoto, Yuko Akioka & Motoshi Hattori

  3. Division of Biochemistry, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan

    Atsushi Tanego

  4. Department of Pediatric Nephrology, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan

    Yoshimitsu Gotoh

  5. Kidney Disease Center, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan

    Makoto Tsujita, Takayuki Yamamoto, Keiji Horike & Asami Takeda

Authors
  1. Yutaka Harita
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  2. Kiyonobu Ishizuka
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Correspondence to Yutaka Harita.

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Harita, Y., Ishizuka, K., Tanego, A. et al. Decreased glomerular filtration as the primary factor of elevated circulating suPAR levels in focal segmental glomerulosclerosis. Pediatr Nephrol 29, 1553–1560 (2014). https://doi.org/10.1007/s00467-014-2808-5

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  • DOI: https://doi.org/10.1007/s00467-014-2808-5

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